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KMID : 1137820100310010027
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의공학회지
2010 Volume.31 No. 1 p.27 ~ p.32
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Mean Phase Coherence as a Supplementary Measure to Diagnose Alzheimer’s Disease with Quantitative Electroencephalogram (qEEG)
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Chae Hui-Je
Jung Young-Jin
Lee Seung-Hwan
Im Chang-Hwan
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Abstract
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Noninvasive detection of patients with probable Alzheimer’s disease (AD) is of great importance for assisting a medical doctor’s decision for early treatment of AD patients. In the present study, we have extracted quantitative electroencephalogram (qEEG) variables, which can be potentially used to diagnose AD, from resting eyes-closed continuous EEGs of 22 AD patients and 27 age-matched normal control (NC) subjects. We have extracted qEEG variables from mean phase coherence (MPC) and EEG coherence, evaluated for all possible combinations of electrode pairs. Preliminary trials to discriminate the two groups with the extracted qEEG variables demonstrated that the use of MPC as a supplementary or alternative measure for the EEG coherence may enhance the accuracy of noninvasive diagnosis of AD.
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KEYWORD
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Alzheimer’s disease (AD), dementia, EEG coherence, mean phase coherence (MPC), quantitative electroencephalogram (qEEG)
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